ABCD1

Across TCGA pan-cancer cohorts, ABCD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ABCD1 data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ABCD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ABCD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where ABCD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.542	0.886	.016	5	view →
PDAC	DFS	Quartile	All	0.288	0.515	.011	4	view →
CCRCC	OS	Median	All	0.730	1.000	.023	3	view →
LUAD	OS	Median	III,IV	0.665	0.235	.023	2	view →
GBM	OS	Median	All	0.447	0.636	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ABCD1–LSCC (OS)

Open the LSCC breakdown →