ABCC8

Across TCGA patient cohorts, ABCC8 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC8-associated genes across cancer lineages are Cyclin-B1, FASN, and GAPDH. Each is linked with ABCC8 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCC8-to-partner and partner-to-ABCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ABCC8-low versus ABCC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC8→partner) and Y-score (partner→ABCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.569	+1.722	<.001	<.001	3	5
STAD	FASN →	+0.367	+2.185	.021	.032	3	4
LUSC	GAPDH →	+0.897	+1.883	.001	.031	3	4
COAD	MYH11 →	-1.302	-2.321	.008	.033	3	4
STAD	ASNS →	+0.389	+3.000	.021	.033	3	4
LUAD	INPP4B →	-0.409	-3.568	.036	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Cyclin-B1 by ABCC8 expression — UCEC

Explore this box plot interactively →