ABCC8

Across TCGA cell cohorts, ABCC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,687 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ABCC8-associated GO terms across cancer lineages are Regulation of potassium ion transport, Positive regulation of ERK1 and ERK2 cascade, and Protein transmembrane transport. Each is linked with ABCC8 in more than 8 cancer types. Because this analysis shows association rather than direction, both ABCC8-to-partner and partner-to-ABCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of potassium ion transport grouped by ABCC8-low versus ABCC8-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC8→partner) and Y-score (partner→ABCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of potassium ion transport →	-0.102	-0.949	<.001	<.001	3	9
BREAST	Positive regulation of ERK1 and ERK2 cascade →	-0.064	-1.615	<.001	.001	3	9
LUNG_SCLC	Protein transmembrane transport →	+0.060	+2.198	<.001	<.001	3	8
PANCREAS	Regulation of cytosolic calcium ion concentration →	-0.136	-0.569	<.001	.009	3	8
SOFT_TISSUE	Regulation of blood pressure →	-0.136	-0.753	<.001	<.001	3	8
BREAST	Positive regulation of potassium ion transport →	-0.123	-0.900	.002	.003	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,687 associations by consensus.

Regulation of potassium ion transport by ABCC8 expression — BREAST

Explore this box plot interactively →