ABCC8

Across TCGA cell cohorts, ABCC8 mutation is significantly associated with the RNA expression of many other genes, with 1,160 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCC8-associated genes across cancer lineages are ARL2BP, ARL6, and FBXO36. Each is linked with ABCC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCC8-to-partner and partner-to-ABCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL2BP grouped by ABCC8-low versus ABCC8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC8→partner) and Y-score (partner→ABCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARL2BP →	+0.492	+3.237	.005	.003	3	3
BLOOD_Leukemia	ARL6 →	+0.725	+3.199	<.001	.007	3	3
LARGE_INTESTINE	FBXO36 →	+0.598	+2.364	<.001	<.001	3	3
LARGE_INTESTINE	TMEM107 →	+0.747	+2.364	.003	<.001	3	3
LARGE_INTESTINE	FOXJ2 →	+0.613	+2.364	.001	<.001	3	3
URINARY_TRACT	IL22 →	+0.017	+4.087	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,160 associations by consensus.

ARL2BP by ABCC8 expression — LARGE_INTESTINE

Explore this box plot interactively →