ABCC6

Across TCGA pan-cancer cohorts, ABCC6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ABCC6 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ABCC6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ABCC6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where ABCC6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.928	0.594	.009	22	view →
LSCC	DFS	Median	II,III,IV	0.827	1.000	.032	3	view →
LUAD	OS	Median	III,IV	0.593	0.194	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ABCC6–CCRCC (OS)

Open the CCRCC breakdown →