ABCC6

Across TCGA patient cohorts, ABCC6 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC6-associated genes across cancer lineages are ATM, p90 RSK, and PCNA. Each is linked with ABCC6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCC6-to-partner and partner-to-ABCC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ABCC6-low versus ABCC6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC6→partner) and Y-score (partner→ABCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.451	-3.313	.013	.010	3	4
SKCM	p90 RSK →	+0.148	+2.000	.017	.007	3	3
SKCM	PCNA →	+0.177	+2.087	.001	.004	3	3
UCEC	Cyclin-B1 →	+0.473	+2.247	.001	.001	3	3
UCEC	Chk2_pT68 →	-0.104	-1.142	.037	.048	3	3
STAD	c-Kit →	-0.395	-3.169	.005	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by ABCC6 expression — COAD

Explore this box plot interactively →