ABCC6

Across TCGA cell cohorts, ABCC6 mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCC6-associated genes across cancer lineages are FBXW10, PIAS2, and C9orf92. Each is linked with ABCC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCC6-to-partner and partner-to-ABCC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by ABCC6-low versus ABCC6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC6→partner) and Y-score (partner→ABCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXW10 →	+0.041	+3.540	.001	.005	3	2
LARGE_INTESTINE	PIAS2 →	+0.878	+3.169	.002	.009	3	2
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
BREAST	IFNA21 →	+0.020	+4.672	<.001	.002	3	1
BREAST	SPZ1 →	+0.018	+4.963	.001	.001	3	1
BREAST	IL25 →	+0.024	+4.672	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

FBXW10 by ABCC6 expression — BLOOD_Leukemia

Explore this box plot interactively →