ABCC5

Across TCGA patient cohorts, ABCC5 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC5-associated genes across cancer lineages are Cyclin-E2, ASNS, and YAP_pS127. Each is linked with ABCC5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCC5-to-partner and partner-to-ABCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ABCC5-low versus ABCC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC5→partner) and Y-score (partner→ABCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.186	+2.347	.048	.018	3	4
COAD	ASNS →	+0.644	+3.321	<.001	.009	3	4
STAD	YAP_pS127 →	-0.356	-3.000	.034	.036	2	4
LUAD	p27_pT157 →	+0.341	+3.000	<.001	.036	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.330	-1.415	.021	.043	3	3
UCEC	PTEN →	-0.268	-1.289	.035	.023	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Cyclin-E2 by ABCC5 expression — COAD

Explore this box plot interactively →