ABCC4

Across TCGA pan-cancer cohorts, ABCC4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ABCC4 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ABCC4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and SKCM are the cancer types where ABCC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.068	0.674	<.001	31	view →
UCEC	DFS	Median	All	0.966	0.823	.005	28	view →
SKCM	OS	Median	III,IV	0.541	0.822	.002	8	view →
BRCA	OS	Median	II,III,IV	0.112	0.565	.022	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.023	6	view →
LIHC	OS	Median	All	0.528	0.779	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ABCC4–ACC (DFS)

Open the ACC breakdown →