ABCC4

Across TCGA pan-cancer cohorts, ABCC4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ABCC4 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ABCC4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCC4 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

OV, LSCC, and HNSC are the cancer types where ABCC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.562	0.942	.004	24	view →
LSCC	DFS	Quartile	All	0.293	1.000	.004	15	view →
HNSC	DFS	Median	IV	0.515	0.789	.008	8	view →
CCRCC	DFS	Tertile	III,IV	0.198	0.830	.024	6	view →
GBM	DFS	Quartile	All	0.613	0.831	.024	3	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ABCC4–OV (DFS)

Open the OV breakdown →