ABCC4

Across TCGA patient cohorts, ABCC4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC4-associated genes across cancer lineages are ASNS, ATM, and c-Met_pY1235. Each is linked with ABCC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCC4-to-partner and partner-to-ABCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ABCC4-low versus ABCC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC4→partner) and Y-score (partner→ABCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.294	+1.362	.006	.034	3	3
UCEC	ATM →	-0.437	-1.736	.001	.006	3	3
UCEC	c-Met_pY1235 →	+0.054	+1.331	.014	.017	3	3
LUAD	C-Raf_pS338 →	+0.157	+3.033	.007	.018	2	3
UCEC	JNK2 →	+0.216	+1.584	<.001	.002	3	2
UCEC	ERK2 →	+0.164	+1.678	.004	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ASNS by ABCC4 expression — UCEC

Explore this box plot interactively →