ABCC4

Across TCGA cell cohorts, ABCC4 mutation is significantly associated with the RNA expression of many other genes, with 292 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCC4-associated genes across cancer lineages are C9orf135, OR13C5, and UCMA. Each is linked with ABCC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCC4-to-partner and partner-to-ABCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf135 grouped by ABCC4-low versus ABCC4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC4→partner) and Y-score (partner→ABCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C9orf135 →	+0.073	+3.906	<.001	.009	3	2
BLOOD_Myeloma	OR13C5 →	+0.363	+3.906	.002	.009	3	2
BREAST	UCMA →	+0.025	+3.963	<.001	.003	3	2
OVARY	TEDDM1 →	+0.026	+2.544	.007	.009	3	2
LARGE_INTESTINE	LARP1B →	+0.611	+2.502	.005	.005	3	2
LARGE_INTESTINE	SLMAP →	+0.405	+2.502	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 292 associations by consensus.

C9orf135 by ABCC4 expression — BLOOD_Myeloma

Explore this box plot interactively →