ABCC3

Across TCGA pan-cancer cohorts, ABCC3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ABCC3 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ABCC3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ABCC3 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

GBM, COAD, and LSCC are the cancer types where ABCC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.713	0.932	<.001	20	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	18	view →
LSCC	OS	Median	All	0.724	0.886	.008	16	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	6	view →
PDAC	OS	Quartile	II,III,IV	1.000	0.813	.023	4	view →
HNSC	OS	Quartile	IV	0.878	0.538	.012	2	view →
LUAD	OS	Quartile	All	1.000	0.927	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ABCC3–GBM (OS)

Open the GBM breakdown →