ABCC3

Across TCGA patient cohorts, ABCC3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC3-associated genes across cancer lineages are c-Met_pY1235, Src, and VHL. Each is linked with ABCC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCC3-to-partner and partner-to-ABCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by ABCC3-low versus ABCC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC3→partner) and Y-score (partner→ABCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.045	+1.087	.043	.048	3	3
CESC	Src →	-0.350	-3.000	.003	.033	3	2
CESC	VHL →	-0.938	-2.999	.008	.031	3	2
SKCM	AMPK_alpha →	+0.087	+1.157	.027	.012	3	2
SKCM	CD49b →	+0.154	+1.174	.018	.008	3	2
UCEC	mTOR_pS2448 →	-0.108	-1.658	.016	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

c-Met_pY1235 by ABCC3 expression — UCEC

Explore this box plot interactively →