ABCC3

Across TCGA cell cohorts, ABCC3 mutation is significantly associated with the RNA expression of many other genes, with 1,614 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABCC3-associated genes across cancer lineages are BRMS1L, MTMR9, and TBC1D19. Each is linked with ABCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCC3-to-partner and partner-to-ABCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRMS1L grouped by ABCC3-low versus ABCC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC3→partner) and Y-score (partner→ABCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRMS1L →	+0.434	+1.850	.008	.006	3	2
LARGE_INTESTINE	MTMR9 →	+0.496	+3.321	<.001	.003	3	2
BLOOD_Leukemia	TBC1D19 →	+0.625	+3.614	<.001	<.001	3	2
LARGE_INTESTINE	ZNF410 →	+0.341	+2.459	.003	.006	3	2
LARGE_INTESTINE	ZFP30 →	+1.010	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	DESI2 →	+0.426	+1.850	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,614 associations by consensus.

BRMS1L by ABCC3 expression — LARGE_INTESTINE

Explore this box plot interactively →