ABCC1

Across TCGA patient cohorts, ABCC1 mutation is significantly associated with the RNA expression of many other genes, with 5,216 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC1-associated genes across cancer lineages are ZWINT, CENPU, and BUB3. Each is linked with ABCC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCC1-to-partner and partner-to-ABCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by ABCC1-low versus ABCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC1→partner) and Y-score (partner→ABCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.627	+2.000	<.001	<.001	3	5
UCEC	CENPU →	+0.587	+1.656	<.001	<.001	3	4
UCEC	BUB3 →	+0.360	+1.741	<.001	<.001	3	4
UCEC	EME1 →	+0.502	+1.635	<.001	<.001	3	4
UCEC	H2AZ1 →	+0.514	+1.501	<.001	<.001	3	4
COAD	TLCD3A →	+0.619	+3.710	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,216 associations by consensus.

ZWINT by ABCC1 expression — UCEC

Explore this box plot interactively →