ABCC1

Across TCGA cell cohorts, ABCC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,288 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABCC1-associated GO terms across cancer lineages are Xenobiotic transport across blood-brain barrier, Cobalamin transport, and Multi-pass transmembrane protein insertion into ER membrane. Each is linked with ABCC1 in more than 15 cancer types. Because this analysis shows association rather than direction, both ABCC1-to-partner and partner-to-ABCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Xenobiotic transport across blood-brain barrier grouped by ABCC1-low versus ABCC1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC1→partner) and Y-score (partner→ABCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Xenobiotic transport across blood-brain barrier →	+1.273	+1.037	<.001	.004	3	16
LUNG_NSCLC_LUSC	Cobalamin transport →	+0.258	+1.721	.002	.007	3	13
LUNG_SCLC	Multi-pass transmembrane protein insertion into ER membrane →	+0.161	+1.297	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Glutathione transport →	+0.172	+1.047	.005	.008	2	14
SKIN	Sphingolipid translocation →	+0.285	+0.635	.001	<.001	3	13
STOMACH	Symbiont-mediated disruption of host cell PML body →	+0.106	+1.265	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,288 associations by consensus.

Xenobiotic transport across blood-brain barrier by ABCC1 expression — LUNG_SCLC

Explore this box plot interactively →