ABCB9

Across TCGA patient cohorts, ABCB9 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB9-associated genes across cancer lineages are PCNA, ATM, and C-Raf. Each is linked with ABCB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB9-to-partner and partner-to-ABCB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ABCB9-low versus ABCB9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB9→partner) and Y-score (partner→ABCB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.193	+1.765	.010	.013	3	2
UCEC	ATM →	-0.535	-2.070	<.001	.001	3	2
UCEC	C-Raf →	+0.119	+1.440	.016	.024	3	2
UCEC	eIF4E →	+0.160	+1.440	.028	.024	3	1
UCEC	ERK2 →	+0.200	+2.070	.002	.001	3	1
UCEC	MEK1 →	+0.367	+2.415	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PCNA by ABCB9 expression — UCEC

Explore this box plot interactively →