ABCB7

Across TCGA patient cohorts, ABCB7 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB7-associated genes across cancer lineages are FoxM1, eIF4E, and eIF4G. Each is linked with ABCB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB7-to-partner and partner-to-ABCB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ABCB7-low versus ABCB7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB7→partner) and Y-score (partner→ABCB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.158	+1.432	.038	.005	3	2
UCEC	eIF4E →	+0.138	+1.857	.026	<.001	3	1
UCEC	eIF4G →	+0.205	+1.058	.025	.037	3	1
UCEC	IGFBP2 →	-0.502	-1.247	.008	.041	3	1
UCEC	JNK_pT183_Y185 →	-0.125	-1.678	.012	.021	3	1
UCEC	JNK2 →	+0.168	+1.512	.004	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FoxM1 by ABCB7 expression — UCEC

Explore this box plot interactively →