ABCB7

Across TCGA cell cohorts, ABCB7 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,946 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ABCB7-associated GO terms across cancer lineages are Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, Mitotic spindle elongation, and Negative regulation of maintenance of sister chromatid cohesion. Each is linked with ABCB7 in more than 13 cancer types. Because this analysis shows association rather than direction, both ABCB7-to-partner and partner-to-ABCB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery grouped by ABCB7-low versus ABCB7-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB7→partner) and Y-score (partner→ABCB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.154	+0.773	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Mitotic spindle elongation →	+0.221	+0.787	.003	.007	3	12
OVARY	Negative regulation of maintenance of sister chromatid cohesion →	+0.090	+0.531	<.001	.003	3	12
OVARY	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.090	+0.531	<.001	.003	3	12
LUNG_NSCLC_LUSC	Mitotic spindle midzone assembly →	+0.221	+0.787	.003	.007	3	12
BLOOD_Leukemia	Dosage compensation by inactivation of X chromosome →	+0.089	+0.560	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,946 associations by consensus.

Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery by ABCB7 expression — OVARY

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