ABCB7

Across TCGA cell cohorts, ABCB7 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCB7-associated genes across cancer lineages are TMEM82, C5orf52, and OR1B1. Each is linked with ABCB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB7-to-partner and partner-to-ABCB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM82 grouped by ABCB7-low versus ABCB7-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB7→partner) and Y-score (partner→ABCB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM82 →	+0.032	+4.273	<.001	.006	3	1
SKIN	C5orf52 →	+0.030	+4.415	<.001	.007	3	1
SKIN	OR1B1 →	+0.024	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	ASB17 →	+0.049	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR51F2 →	+0.032	+5.662	<.001	.002	3	1
BREAST	GJA10 →	+0.022	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

TMEM82 by ABCB7 expression — SKIN

Explore this box plot interactively →