ABCB6

Across TCGA pan-cancer cohorts, ABCB6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ABCB6 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ABCB6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCB6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where ABCB6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.361	0.860	.022	8	view →
LUAD	OS	Median	All	0.887	0.999	.026	8	view →
PDAC	DFS	Median	All	0.676	0.901	.001	7	view →
UCEC	OS	Median	All	0.852	0.977	.011	4	view →
CCRCC	OS	Median	All	0.970	0.836	.040	1	view →
GBM	DFS	Median	All	0.566	0.786	.012	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ABCB6–HNSC (DFS)

Open the HNSC breakdown →