ABCB6

Across TCGA pan-cancer cohorts, ABCB6 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ABCB6’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ABCB6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ABCB6 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where ABCB6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCB6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.820	<.001	10	view →
COAD	Female	II,III,IV	−0.281	<.001	7	view →
HNSC	All	II,III,IV	−0.224	.002	5	view →
LSCC	All	All	+0.256	.002	4	view →
PDAC	All	All	−0.225	.006	4	view →
OV	All	All	−0.514	.007	2	view →
LUAD	Male	II,III,IV	−0.251	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ABCB6–CCRCC

Open the CCRCC breakdown →