ABCB6

Across TCGA patient cohorts, ABCB6 mutation is significantly associated with the RNA expression of many other genes, with 1,219 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB6-associated genes across cancer lineages are LINC00547, BAG3, and CXCL13. Each is linked with ABCB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB6-to-partner and partner-to-ABCB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00547 grouped by ABCB6-low versus ABCB6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB6→partner) and Y-score (partner→ABCB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC00547 →	+0.184	+4.141	<.001	.002	3	2
UCEC	BAG3 →	+0.583	+2.286	<.001	.005	3	2
UCEC	CXCL13 →	+1.890	+2.807	<.001	<.001	3	2
UCEC	GFI1 →	+0.469	+2.321	<.001	.005	3	2
UCEC	CTLA4 →	+0.614	+2.016	.001	.005	3	2
UCEC	ICOS →	+0.434	+2.550	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,219 associations by consensus.

LINC00547 by ABCB6 expression — SKCM

Explore this box plot interactively →