ABCB6

Across TCGA patient cohorts, ABCB6 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB6-associated genes across cancer lineages are ATM, MEK1, and MSH2. Each is linked with ABCB6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCB6-to-partner and partner-to-ABCB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ABCB6-low versus ABCB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB6→partner) and Y-score (partner→ABCB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.531	-2.794	<.001	.002	3	4
UCEC	MEK1 →	+0.438	+3.169	<.001	<.001	2	3
UCEC	MSH2 →	-0.226	-1.848	.005	.049	3	2
COAD	Caspase-7-cleavedD198 →	+1.193	+2.815	.005	.036	3	2
UCEC	4E-BP1 →	+0.322	+2.392	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.077	-2.295	.030	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by ABCB6 expression — UCEC

Explore this box plot interactively →