ABCB6

Across TCGA cell cohorts, ABCB6 mutation is significantly associated with the mutation status of many other genes, with 5,011 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCB6-associated genes across cancer lineages are ALS2, GSE1, and CDK13. Each is linked with ABCB6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCB6-to-partner and partner-to-ABCB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALS2 grouped by ABCB6-low versus ABCB6-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB6→partner) and Y-score (partner→ABCB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ALS2 →	+3.222	+3.754	.001	.001	1	4
PANCREAS	GSE1 →	+5.115	+5.115	.005	.005	1	4
PANCREAS	CDK13 →	+5.115	+5.115	.005	.005	1	4
SKIN	JARID2 →	+2.830	+3.548	.009	.009	1	4
SKIN	POLRMT →	+3.053	+4.662	<.001	<.001	1	4
SOFT_TISSUE	SMG1 →	+3.777	+3.307	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,011 associations by consensus.

ALS2 by ABCB6 expression — BREAST

Explore this box plot interactively →