ABCB5

Across TCGA pan-cancer cohorts, ABCB5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ABCB5 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ABCB5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCB5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and GBM are the cancer types where ABCB5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.777	1.000	.009	14	view →
UCEC	DFS	Median	II,III,IV	0.915	0.418	.008	4	view →
GBM	OS	Median	All	0.543	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ABCB5–HNSC (DFS)

Open the HNSC breakdown →