ABCB5

Across TCGA patient cohorts, ABCB5 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB5-associated genes across cancer lineages are FoxM1, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with ABCB5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCB5-to-partner and partner-to-ABCB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ABCB5-low versus ABCB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB5→partner) and Y-score (partner→ABCB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.175	+2.415	.009	.002	3	5
UCEC	Cyclin-B1 →	+0.676	+1.584	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.052	+2.915	<.001	<.001	3	4
UCEC	Chk2_pT68 →	-0.115	-2.061	.018	.004	3	4
STAD	Claudin-7 →	+0.839	+3.169	.009	.019	3	3
LUAD	p70-S6K →	+0.170	+2.000	.015	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

FoxM1 by ABCB5 expression — UCEC

Explore this box plot interactively →