ABCB5

Across TCGA cell cohorts, ABCB5 mutation is significantly associated with the RNA expression of many other genes, with 212 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCB5-associated genes across cancer lineages are TEX43, INS, and SCYGR4. Each is linked with ABCB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB5-to-partner and partner-to-ABCB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by ABCB5-low versus ABCB5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB5→partner) and Y-score (partner→ABCB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEX43 →	+0.156	+3.260	<.001	<.001	3	2
LUNG_SCLC	INS →	+0.288	+3.263	<.001	<.001	3	2
LUNG_SCLC	SCYGR4 →	+0.019	+2.781	<.001	.002	3	2
BLOOD_Leukemia	IL36A →	+0.641	+3.656	.002	.006	3	2
STOMACH	HHATL →	+0.086	+3.459	.001	.006	3	2
LARGE_INTESTINE	MAGEB4 →	+0.006	+2.415	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 212 associations by consensus.

TEX43 by ABCB5 expression — LUNG_SCLC

Explore this box plot interactively →