ABCB4

Across TCGA patient cohorts, ABCB4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB4-associated genes across cancer lineages are GAPDH, c-Jun_pS73, and FOXO3a_pS318_S321. Each is linked with ABCB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCB4-to-partner and partner-to-ABCB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ABCB4-low versus ABCB4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB4→partner) and Y-score (partner→ABCB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.659	+3.459	.024	.005	3	4
STAD	c-Jun_pS73 →	-0.257	-3.321	.002	.009	3	3
SKCM	FOXO3a_pS318_S321 →	+0.157	+3.012	.019	.018	3	3
UCEC	Ku80 →	+0.196	+1.382	.002	.002	3	3
UCEC	mTOR_pS2448 →	-0.090	-1.132	.027	.048	3	3
LUAD	PRAS40_pT246 →	-0.129	-3.169	.027	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

GAPDH by ABCB4 expression — SKCM

Explore this box plot interactively →