ABCB11

Across TCGA pan-cancer cohorts, ABCB11 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ABCB11’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ABCB11 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ABCB11 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

LUAD and LSCC are the cancer types where ABCB11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCB11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.379	.011	2	view →
LSCC	All	II,III,IV	−0.253	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

ABCB11–LUAD

Open the LUAD breakdown →