ABCB10

Across TCGA patient cohorts, ABCB10 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB10-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and Bcl-2. Each is linked with ABCB10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB10-to-partner and partner-to-ABCB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ABCB10-low versus ABCB10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB10→partner) and Y-score (partner→ABCB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.471	-3.169	.020	.019	3	2
UCEC	PCNA →	+0.224	+2.321	.021	.034	3	2
UCEC	Bcl-2 →	-0.371	-3.150	.017	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.774	+3.189	.003	.010	3	2
UCEC	Cyclin-B1 →	+0.519	+2.999	.040	.035	3	2
UCEC	Cyclin-E1 →	+0.400	+2.999	.041	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p38-MAPK_pT180_Y182 by ABCB10 expression — UCEC

Explore this box plot interactively →