ABCA9-AS1

Across TCGA pan-cancer cohorts, ABCA9-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ABCA9-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ABCA9-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABCA9-AS1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, LUSC, and COAD are the cancer types where ABCA9-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCA9-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.295	<.001	11	view →
LUSC	Female	All	+0.945	<.001	8	view →
COAD	All	All	+0.245	<.001	8	view →
THCA	All	II,III,IV	−0.066	<.001	7	view →
BRCA	All	III,IV	−0.161	<.001	6	view →
BLCA	All	All	+0.338	.011	4	view →
STAD	All	All	+0.240	.008	3	view →
LUAD	All	All	+0.258	.005	2	view →
KICH	All	All	−0.026	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ABCA9-AS1–HNSC

Open the HNSC breakdown →