ABCA8

Across TCGA patient cohorts, ABCA8 mutation is significantly associated with the RNA expression of many other genes, with 6,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA8-associated genes across cancer lineages are COQ5, KIF4A, and POC1A. Each is linked with ABCA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCA8-to-partner and partner-to-ABCA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ5 grouped by ABCA8-low versus ABCA8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA8→partner) and Y-score (partner→ABCA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	COQ5 →	+0.332	+2.451	.002	<.001	3	5
UCEC	KIF4A →	+0.573	+1.392	<.001	<.001	3	5
UCEC	POC1A →	+0.533	+1.652	<.001	<.001	3	5
UCEC	WDR76 →	+0.654	+1.673	<.001	<.001	3	5
UCEC	PIMREG →	+0.645	+1.540	<.001	<.001	3	5
UCEC	PLEKHB2 →	+0.354	+2.102	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,948 associations by consensus.

COQ5 by ABCA8 expression — LUSC

Explore this box plot interactively →