ABCA8

Across TCGA cell cohorts, ABCA8 mutation is significantly associated with the RNA expression of many other genes, with 976 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCA8-associated genes across cancer lineages are THAP7, SLC24A2, and KRTAP4-2. Each is linked with ABCA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCA8-to-partner and partner-to-ABCA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THAP7 grouped by ABCA8-low versus ABCA8-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA8→partner) and Y-score (partner→ABCA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	THAP7 →	+0.678	+3.220	.003	.005	3	3
LUNG_NSCLC_LUAD	SLC24A2 →	+0.115	+3.184	<.001	.007	3	3
PANCREAS	KRTAP4-2 →	+0.038	+5.000	<.001	.006	3	2
BREAST	C17orf67 →	+0.850	+3.220	<.001	.005	3	2
STOMACH	GOT1 →	+0.916	+3.070	.003	.008	3	2
LARGE_INTESTINE	TTI2 →	+0.646	+2.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 976 associations by consensus.

THAP7 by ABCA8 expression — BREAST

Explore this box plot interactively →