ABCA7

Across TCGA patient cohorts, ABCA7 mutation is significantly associated with the RNA expression of many other genes, with 6,119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA7-associated genes across cancer lineages are SPC24, SLBP, and ZMYND19. Each is linked with ABCA7 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCA7-to-partner and partner-to-ABCA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC24 grouped by ABCA7-low versus ABCA7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA7→partner) and Y-score (partner→ABCA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SPC24 →	+0.499	+2.716	<.001	<.001	3	4
UCEC	SLBP →	+0.473	+1.480	<.001	<.001	3	4
UCEC	ZMYND19 →	+0.369	+1.656	<.001	<.001	3	4
COAD	ZFYVE19 →	+0.502	+3.920	<.001	<.001	3	4
UCEC	CHAF1A →	+0.677	+2.379	<.001	<.001	3	4
COAD	GLOD4 →	+0.478	+3.321	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,119 associations by consensus.

SPC24 by ABCA7 expression — COAD

Explore this box plot interactively →