ABCA7

Across TCGA cell cohorts, ABCA7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,207 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ABCA7-associated GO terms across cancer lineages are Regulation of engulfment of apoptotic cell, Amyloid-beta clearance by cellular catabolic process, and Glycerophospholipid metabolic process. Each is linked with ABCA7 in more than 19 cancer types. Because this analysis shows association rather than direction, both ABCA7-to-partner and partner-to-ABCA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of engulfment of apoptotic cell grouped by ABCA7-low versus ABCA7-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA7→partner) and Y-score (partner→ABCA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of engulfment of apoptotic cell →	+1.675	+2.417	<.001	<.001	3	20
BLOOD_Leukemia	Amyloid-beta clearance by cellular catabolic process →	+0.139	+1.464	<.001	<.001	2	17
OESOPHAGUS	Glycerophospholipid metabolic process →	+0.046	+1.439	.001	.004	3	14
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.048	+1.478	<.001	<.001	3	14
OESOPHAGUS	Oxidative demethylation →	-0.259	-1.736	<.001	<.001	3	14
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.151	+1.025	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,207 associations by consensus.

Regulation of engulfment of apoptotic cell by ABCA7 expression — URINARY_TRACT

Explore this box plot interactively →