ABCA7

Across TCGA cell cohorts, ABCA7 mutation is significantly associated with the RNA expression of many other genes, with 912 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCA7-associated genes across cancer lineages are SEPTIN14, OSGEPL1, and C1QTNF9. Each is linked with ABCA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCA7-to-partner and partner-to-ABCA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14 grouped by ABCA7-low versus ABCA7-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA7→partner) and Y-score (partner→ABCA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SEPTIN14 →	+0.474	+2.938	<.001	.003	3	3
LARGE_INTESTINE	OSGEPL1 →	+0.493	+3.169	.002	.009	3	3
BLOOD_Leukemia	C1QTNF9 →	+0.022	+2.074	<.001	.005	3	3
BLOOD_Myeloma	AMELY →	+0.071	+3.169	.001	.004	3	2
SOFT_TISSUE	OR10K1 →	+0.005	+4.977	<.001	.002	3	2
SOFT_TISSUE	KRTAP2-1 →	+0.123	+4.417	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 912 associations by consensus.

SEPTIN14 by ABCA7 expression — CNS

Explore this box plot interactively →