ABCA6

Across TCGA pan-cancer cohorts, ABCA6 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ABCA6 data layer compared with 17 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ABCA6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ABCA6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and ESCA show a favorable association.

READ, UCEC, and ESCA are the cancer types where ABCA6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	IV	0.111	0.893	<.001	18	view →
UCEC	DFS	Median	All	0.910	0.615	.008	18	view →
ESCA	DFS	Median	IV	0.826	0.284	.034	12	view →
UVM	OS	Median	All	0.249	0.712	.033	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.322	0.730	<.001	6	view →
BLCA	DFS	Median	II,III,IV	0.827	0.329	.044	4	view →
SCLC	DFS	Median	II,III,IV	1.000	0.349	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ABCA6–READ (OS)

Open the READ breakdown →