ABCA6

Across TCGA patient cohorts, ABCA6 mutation is significantly associated with the RNA expression of many other genes, with 5,931 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ABCA6-associated genes across cancer lineages are KRT18P14, NDC80, and SYNJ2BP-COX16. Each is linked with ABCA6 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCA6-to-partner and partner-to-ABCA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT18P14 grouped by ABCA6-low versus ABCA6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA6→partner) and Y-score (partner→ABCA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KRT18P14 →	+0.027	+1.317	<.001	.007	3	5
SKCM	NDC80 →	+0.568	+1.652	<.001	.005	3	5
SKCM	SYNJ2BP-COX16 →	+0.298	+1.664	<.001	<.001	3	4
SKCM	ASB7 →	+0.423	+2.610	<.001	<.001	3	4
SKCM	C17orf58 →	+0.344	+2.321	.004	<.001	3	4
SKCM	MED8 →	+0.342	+2.133	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,931 associations by consensus.

KRT18P14 by ABCA6 expression — SKCM

Explore this box plot interactively →