ABCA5

Across TCGA patient cohorts, ABCA5 mutation is significantly associated with the RNA expression of many other genes, with 6,296 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA5-associated genes across cancer lineages are SLC35B1, CHAF1B, and OR8Q1P. Each is linked with ABCA5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCA5-to-partner and partner-to-ABCA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35B1 grouped by ABCA5-low versus ABCA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA5→partner) and Y-score (partner→ABCA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC35B1 →	+0.462	+2.379	<.001	<.001	3	4
UCEC	CHAF1B →	+0.559	+1.624	<.001	<.001	3	4
LIHC	OR8Q1P →	+0.266	+4.464	<.001	.002	3	3
LUAD	OIP5 →	+1.115	+3.482	<.001	.002	3	3
LIHC	SPANXC →	+0.435	+4.230	<.001	.003	3	3
LGG	COX5BP1 →	+0.152	+6.632	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,296 associations by consensus.

SLC35B1 by ABCA5 expression — UCEC

Explore this box plot interactively →