ABCA5

Across TCGA patient cohorts, ABCA5 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA5-associated genes across cancer lineages are ASNS, Di-Ras3, and eIF4E. Each is linked with ABCA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCA5-to-partner and partner-to-ABCA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ABCA5-low versus ABCA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA5→partner) and Y-score (partner→ABCA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.354	+1.736	<.001	.005	3	3
UCEC	Di-Ras3 →	-0.117	-2.489	.003	.001	3	3
UCEC	eIF4E →	+0.148	+2.137	.010	<.001	3	2
UCEC	ERK2 →	+0.149	+1.353	.004	.013	3	2
UCEC	Notch1 →	+0.099	+1.405	.009	.009	3	2
UCEC	PDCD4 →	-0.329	-0.951	.010	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ASNS by ABCA5 expression — UCEC

Explore this box plot interactively →