ABCA5

Across TCGA cell cohorts, ABCA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,213 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABCA5-associated GO terms across cancer lineages are Protein targeting to lysosome, Golgi vesicle transport, and Establishment of protein localization to vacuole. Each is linked with ABCA5 in more than 10 cancer types. Because this analysis shows association rather than direction, both ABCA5-to-partner and partner-to-ABCA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to lysosome grouped by ABCA5-low versus ABCA5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA5→partner) and Y-score (partner→ABCA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein targeting to lysosome →	+0.088	+1.103	<.001	<.001	3	11
OVARY	Golgi vesicle transport →	+0.065	+1.090	<.001	.007	3	11
LUNG_NSCLC_LUSC	Establishment of protein localization to vacuole →	+0.072	+1.541	.001	.006	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.106	+1.082	.001	.001	3	10
PANCREAS	Endoplasmic reticulum to cytosol transport →	+0.112	+0.897	.005	.008	3	10
PANCREAS	Retrograde protein transport, ER to cytosol →	+0.112	+0.897	.005	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,213 associations by consensus.

Protein targeting to lysosome by ABCA5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →