ABCA3

Across TCGA patient cohorts, ABCA3 mutation is significantly associated with the RNA expression of many other genes, with 7,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA3-associated genes across cancer lineages are PTMAP4, CHAF1B, and SPC24. Each is linked with ABCA3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ABCA3-to-partner and partner-to-ABCA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTMAP4 grouped by ABCA3-low versus ABCA3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA3→partner) and Y-score (partner→ABCA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTMAP4 →	+1.569	+2.834	<.001	<.001	3	6
UCEC	CHAF1B →	+0.681	+1.725	<.001	<.001	3	5
UCEC	SPC24 →	+0.421	+1.584	.004	<.001	3	5
UCEC	POC1A →	+0.549	+1.450	<.001	<.001	3	5
UCEC	ZNF367 →	+0.696	+1.725	<.001	<.001	3	5
UCEC	CHAF1A →	+0.709	+2.406	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,138 associations by consensus.

PTMAP4 by ABCA3 expression — COAD

Explore this box plot interactively →