ABCA3

Across TCGA cell cohorts, ABCA3 mutation is significantly associated with the RNA expression of many other genes, with 1,157 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCA3-associated genes across cancer lineages are MSH4, OR13D1, and INSL5. Each is linked with ABCA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCA3-to-partner and partner-to-ABCA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH4 grouped by ABCA3-low versus ABCA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA3→partner) and Y-score (partner→ABCA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSH4 →	+0.247	+3.321	<.001	.002	3	4
URINARY_TRACT	OR13D1 →	+0.032	+4.217	<.001	.005	3	2
PANCREAS	INSL5 →	+0.046	+3.222	<.001	.006	3	2
PANCREAS	C12orf40 →	+0.032	+3.201	<.001	.008	3	2
PANCREAS	CALN1 →	+0.207	+3.222	.001	.006	3	2
PANCREAS	SLC22A25 →	+0.011	+3.201	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,157 associations by consensus.

MSH4 by ABCA3 expression — LARGE_INTESTINE

Explore this box plot interactively →