ABCA2

Across TCGA pan-cancer cohorts, ABCA2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ABCA2 data layer compared with 23 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ABCA2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ABCA2 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where ABCA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.658	1.000	.002	35	view →
CCRCC	OS	Tertile	II,III,IV	0.804	1.000	.029	8	view →
PDAC	OS	Tertile	All	0.287	0.782	.038	6	view →
GBM	OS	Tertile	All	0.336	0.625	.038	2	view →
LUAD	DFS	Quartile	All	1.000	0.459	.007	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ABCA2–LSCC (OS)

Open the LSCC breakdown →