ABCA2

Across TCGA cell cohorts, ABCA2 mutation is significantly associated with the RNA expression of many other genes, with 1,807 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCA2-associated genes across cancer lineages are FBXW7, SGCB, and CLDN24. Each is linked with ABCA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCA2-to-partner and partner-to-ABCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW7 grouped by ABCA2-low versus ABCA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA2→partner) and Y-score (partner→ABCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXW7 →	+0.967	+2.936	<.001	<.001	3	3
BLOOD_Leukemia	SGCB →	+1.238	+2.252	<.001	.003	3	3
BREAST	CLDN24 →	+0.136	+3.443	<.001	.009	3	3
LARGE_INTESTINE	ARMC1 →	+0.332	+1.721	.005	.003	3	3
LARGE_INTESTINE	MRPS15 →	+0.456	+3.404	<.001	<.001	3	3
LARGE_INTESTINE	CEP97 →	+0.577	+2.179	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,807 associations by consensus.

FBXW7 by ABCA2 expression — BLOOD_Leukemia

Explore this box plot interactively →