ABCA12

Across TCGA pan-cancer cohorts, ABCA12 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated ABCA12 data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ABCA12 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCA12 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

KICH, UCS, and BRCA are the cancer types where ABCA12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.043	0.971	<.001	33	view →
UCS	OS	Median	II,III,IV	0.004	0.634	<.001	24	view →
BRCA	OS	Median	All	0.614	0.926	<.001	18	view →
BLCA	DFS	Median	II,III,IV	0.599	0.323	.021	15	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
UCEC	OS	Median	IV	0.239	0.625	.012	12	view →
LUAD	DFS	Median	All	0.904	0.322	.011	6	view →
LIHC	DFS	Median	All	0.070	0.531	<.001	5	view →
SKCM	DFS	Median	III,IV	0.106	0.670	<.001	5	view →
OV	DFS	Median	IV	0.726	0.239	.043	4	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
COAD	OS	Median	III,IV	0.183	0.696	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

ABCA12–KICH (DFS)

Open the KICH breakdown →