AATK

Across TCGA patient cohorts, AATK protein abundance is significantly associated with the RNA expression of many other genes, with 5,536 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AATK-associated genes across cancer lineages are PHACTR3, SLC1A4, and NDUFB10. Each is linked with AATK in more than 2 cancer types. Because this analysis shows association rather than direction, both AATK-to-partner and partner-to-AATK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AATK versus PHACTR3 in GBM, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AATK→partner) and Y-score (partner→AATK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PHACTR3 →	+1.320	+0.615	<.001	<.001	3	3
LSCC	SLC1A4 →	-0.747	-0.548	<.001	<.001	3	2
LUAD	NDUFB10 →	-0.407	-0.787	.001	.005	3	2
LSCC	GRHL3 →	-2.229	-0.712	<.001	<.001	3	2
LSCC	CCDC117 →	-0.470	-0.730	<.001	<.001	3	2
LSCC	SYTL3 →	+0.742	+0.498	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,536 associations by consensus.

AATK vs PHACTR3 — GBM

Explore this scatter interactively →