AATK

Across TCGA patient cohorts, AATK mutation is significantly associated with the RNA expression of many other genes, with 1,671 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AATK-associated genes across cancer lineages are RNU6-836P, H2AC14, and GAPDHP41. Each is linked with AATK in more than 2 cancer types. Because this analysis shows association rather than direction, both AATK-to-partner and partner-to-AATK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-836P grouped by AATK-low versus AATK-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AATK→partner) and Y-score (partner→AATK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-836P →	+0.228	+4.116	<.001	.009	3	3
UCEC	H2AC14 →	+0.688	+2.823	<.001	.001	3	3
LIHC	GAPDHP41 →	+0.055	+4.119	<.001	.004	3	2
STAD	RNA5SP393 →	+0.483	+3.353	<.001	.003	3	2
STAD	RNU6-362P →	+0.323	+3.350	<.001	.004	3	2
LIHC	RNA5SP243 →	+0.756	+4.413	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,671 associations by consensus.

RNU6-836P by AATK expression — LUSC

Explore this box plot interactively →